Therapeutic Penetrating Keratoplasty Button Cultures in The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole Versus Placebo.

ABSTRACT:

Objective

To compare oral voriconazole vs placebo in addition to topical antifungals in the treatment of filamentous fungal keratitis.

Design

Non-prespecified, secondary case-control analysis from a multicenter, double-masked, randomized placebo-controlled clinical trial.

Methods

Study Participants: Patients with smear-positive filamentous fungal ulcers and visual acuity of 20/400 or worse who eventuated to therapeutic penetrating keratoplasty (TPK).

Intervention

Study participants were randomized to oral voriconazole vs oral placebo; all received topical antifungal drops.

Main outcome measures

TPK button culture positivity.

Results

A total of 95 of 194 (49.5%) study participants enrolled at Madurai, Coimbatore, or Pondicherry, India eventuated to

SUBMITTER: Cho J 

PROVIDER: S-EPMC6584760 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature