Substrate cross-feeding affects the speed and trajectory of molecular evolution within a synthetic microbial assemblage.

ABSTRACT:

Background

Substrate cross-feeding occurs when one organism partially consumes a primary substrate into one or more metabolites while other organisms then consume the metabolites. While pervasive within microbial communities, our knowledge about the effects of substrate cross-feeding on microbial evolution remains limited. To address this knowledge gap, we experimentally evolved isogenic nitrite (NO₂^-) cross-feeding microbial strains together for 700 generations, identified genetic changes that were acquired over the evolution experiment, and compared the results with an isogenic completely denitrifying strain that was evolved alone for 700 generations. We further investigated how the magnitude of interdependence between the nitrite cross-feeding strains affec

SUBMITTER: Lilja EE 

PROVIDER: S-EPMC6584980 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature