Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data.

ABSTRACT:

Background

Drug repurposing is a swift, safe, and cheap drug discovery method. Melanoma disorders present low survival and high mortality rates and are challenging to diagnose and treat. Moreover, there is a high volume of worldwide investigations that are attempting to find melanoma-related genes of influence, which can be identified as responsive targets for reliable treatment.

Method

In this study, we used a wide range of data analyses to analyze over 1100 genes and proteins of influence with respect to cutaneous malignant melanoma. Our analysis included various investigational results from genome- and phenome-wide association studies (GWAS and PheWAS, respectively), biomedical, transcriptomic, and metabolomic datasets. We then researched the DrugBank for potential melano

SUBMITTER: Khosravi A 

PROVIDER: S-EPMC6584997 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature