Dynamic DNA methylation of ovaries during pubertal transition in gilts.

ABSTRACT:

Background

In female mammals, the initiation of puberty, coupling with the dramatically morphological changes in ovaries, indicates the sexual and follicular maturation. Previous studies have suggested that the disrupted DNA methylation results in the delayed puberty. However, to date, the changes in ovarian methylomes during pubertal transition have not been investigated. In this study, using gilts as a pubertal model, the genome-wide DNA methylation were profiled to explore their dynamics during pubertal transition across Pre-, In- and Post-puberty.

Results

During pubertal transition, the follicles underwent maturation and luteinization, coupled with the significant changes in the mRNA expression of DNMT1 and DNMT3a. DNA methylation levels of In-puberty were higher than th

SUBMITTER: Yuan X 

PROVIDER: S-EPMC6585006 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature