Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals.

ABSTRACT:

Background

The hypothesis that vertebrates have experienced two ancient, whole genome duplications (WGDs) is of central interest to evolutionary biology and has been implicated in evolution of developmental complexity. Three-way and Four-way paralogy regions in human and other vertebrate genomes are considered as vital evidence to support this hypothesis. Alternatively, it has been proposed that such paralogy regions are created by small-scale duplications that occurred at different intervals over the evolution of life.

Results

To address this debate, the present study investigates the evolutionary history of multigene families with at least three-fold representation on human chromosomes 1, 2, 8 and 20. Phylogenetic analysis and the tree topology comparisons classified the m

SUBMITTER: Pervaiz N 

PROVIDER: S-EPMC6585022 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature