Genome-wide enhancer annotations differ significantly in genomic distribution, evolution, and function.

ABSTRACT:

Background

Non-coding gene regulatory enhancers are essential to transcription in mammalian cells. As a result, a large variety of experimental and computational strategies have been developed to identify cis-regulatory enhancer sequences. Given the differences in the biological signals assayed, some variation in the enhancers identified by different methods is expected; however, the concordance of enhancers identified by different methods has not been comprehensively evaluated. This is critically needed, since in practice, most studies consider enhancers identified by only a single method. Here, we compare enhancer sets from eleven representative strategies in four biological contexts.

Results

All sets we evaluated overlap significantly more than expected by chance; however

SUBMITTER: Benton ML 

PROVIDER: S-EPMC6585034 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature