DNA methylation signature of human hippocampus in Alzheimer's disease is linked to neurogenesis.

ABSTRACT:

Background

Drawing the epigenome landscape of Alzheimer's disease (AD) still remains a challenge. To characterize the epigenetic molecular basis of the human hippocampus in AD, we profiled genome-wide DNA methylation levels in hippocampal samples from a cohort of pure AD patients and controls by using the Illumina 450K methylation arrays.

Results

Up to 118 AD-related differentially methylated positions (DMPs) were identified in the AD hippocampus, and extended mapping of specific regions was obtained by bisulfite cloning sequencing. AD-related DMPs were significantly correlated with phosphorylated tau burden. Functional analysis highlighted that AD-related DMPs were enriched in poised promoters that were not generally maintained in committed neural progenitor cells, as shown

SUBMITTER: Altuna M 

PROVIDER: S-EPMC6585076 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature