Antipsychotic drug use and risk of stroke and myocardial infarction: a systematic review and meta-analysis.

ABSTRACT:

Background

The effect of antipsychotic (AP) drugs on risk of stroke and myocardial infarction (MI) remains unclear due to methodological limitations of, and inconsistencies across, existing studies. We aimed to systematically review studies reporting on the associations between AP drug use and stroke or MI risk, and to investigate whether associations differed among different sub-populations.

Methods

We searched Medline, EMBASE, PsychINFO and Cochrane Library (from inception to May 28, 2017) for observational studies reporting on AP drug use and MI or stroke occurrence. We performed random-effects meta-analyses for each outcome, performing sub-groups analyses by study population - specifically general population (i.e. those not restricted to patients with a particular indica

SUBMITTER: Zivkovic S 

PROVIDER: S-EPMC6585081 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature