Association of plasma endothelial lipase levels on cognitive impairment.

ABSTRACT:

Background

Peripheral high-density lipoprotein cholesterol (HDL-C) has been known to influx into the brain and be inversely associated with the risk of Alzheimer's disease (AD). However, recent prospective studies of the association between HDL-C and AD have yielded inconsistent results. Here, we examined the association between the endothelial lipase (EL), which is known to be major determinant of HDL-C levels, and cognitive function.

Method

We compared plasma from 20 patients with Alzheimer's disease (AD), 38 persons with mild cognitive impairment, and 51 cognitively normal controls. Plasma EL levels were measured using the enzyme-linked immunosorbent assay.

Results

EL levels were inversely correlated with HDL-C, as previously reported; however, there were no mean d

SUBMITTER: Yun SM 

PROVIDER: S-EPMC6585097 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature