A novel AR translational regulator lncRNA LBCS inhibits castration resistance of prostate cancer.

ABSTRACT:

Background

Progression to a castration resistance state is the main cause of deaths in prostate cancer (PCa) patients. Androgen Receptor (AR) signaling plays the central role in progression of Castration Resistant Prostate Cancer (CRPC), therefore understanding the mechanisms of AR activation in the milieu of low androgen is critical to discover novel approach to treat CRPC.

Methods

Firstly, we explore the CRPC associated lncRNAs by transcriptome microarray. The expression and clinical features of lnc-LBCS are analyzed in three independent large-scale cohorts. The functional role and mechanism of lnc-LBCS are further investigated by gain and loss of function assays in vitro.

Results

The expression of Lnc-LBCS was lower in CRPC cells lines and tissues. LBCS downregulat

SUBMITTER: Gu P 

PROVIDER: S-EPMC6585145 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature