Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease.

ABSTRACT: Background Recent studies have revealed sexually dimorphic associations between the carbamoyl-phosphate synthase 1 locus, intermediates of the metabolic pathway leading from choline to urea, and risk of coronary artery disease ( CAD ) in women. Based on evidence from the literature, the atheroprotective association with carbamoyl-phosphate synthase 1 could be mediated by the strong genetic effect of this locus on increased circulating glycine levels. Methods and Results We sought to identify additional genetic determinants of circulating glycine levels by carrying out a meta-analysis of genome-wide association study data in up to 30 118 subjects of European ancestry. Mendelian randomization and other analytical approaches were used to determine whether glycine-associated variants were asso

SUBMITTER: Jia Q 

PROVIDER: S-EPMC6585317 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature