Telomere Length and Vascular Phenotypes in a Population-Based Cohort of Children and Midlife Adults.

ABSTRACT: Background Telomere length has been inversely associated with cardiovascular disease in adulthood, but its relationship to preclinical cardiovascular phenotypes across the life course remains unclear. We investigated associations of telomere length with vascular structure and function in children and midlife adults. Methods and Results Population-based cross-sectional CheckPoint (Child Health CheckPoint) study of 11- to 12-year-old children and their parents, nested within the LSAC (Longitudinal Study of Australian Children). Telomere length (telomeric genomic DNA [T]/β-globin single-copy gene [S] [T/S ratio]) was measured by quantitative polymerase chain reaction from blood-derived genomic DNA. Vascular structure was assessed by carotid intima-media thickness, and vascular function was as

SUBMITTER: Nguyen MT 

PROVIDER: S-EPMC6585377 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature