Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved.

ABSTRACT: The pathological implication of amyloid precursor protein (APP) in Alzheimer's disease has been widely documented due to its involvement in the generation of amyloid-β peptide. However, the physiological functions of APP are still poorly understood. APP is considered a multimodal protein due to its role in a wide variety of processes, both in the embryo and in the adult brain. Specifically, APP seems to play a key role in the proliferation, differentiation and maturation of neural stem cells. In addition, APP can be processed through two canonical processing pathways, generating different functionally active fragments: soluble APP-α, soluble APP-β, amyloid-β peptide and the APP intracellular C-terminal domain. These fragments also appear to modulate various functions in neural stem cells,

SUBMITTER: Coronel R 

PROVIDER: S-EPMC6585543 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature