Differences in pathological changes between two rat models of severe traumatic brain injury.

ABSTRACT: The rat high-impact free weight drop model mimics the diffuse axonal injury caused by severe traumatic brain injury in humans, while severe controlled cortical impact can produce a severe traumatic brain injury model using precise strike parameters. In this study, we compare the pathological mechanisms and pathological changes between two rat severe brain injury models to identify the similarities and differences. The severe controlled cortical impact model was produced by an electronic controlled cortical impact device, while the severe free weight drop model was produced by dropping a 500 g free weight from a height of 1.8 m through a plastic tube. Body temperature and mortality were recorded, and neurological deficits were assessed with the modified neurological severity score. Brain ed

SUBMITTER: Song YM 

PROVIDER: S-EPMC6585550 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature