Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study.

ABSTRACT:

Aim

Hyperphosphataemia is associated with increased mortality and morbidity in end stage renal disease. Despite phosphate binder therapy, a large proportion of patients do not reach the treatment target. In five contemporary binders we explored the influence of pH and phosphate concentration on phosphate binding. This interaction could be of relevance in clinical practice.

Methods

Phosphate binding was quantified in vitro in 25 mL of purified water containing phosphate concentrations of 10, 15 and 20 mM and baseline pH values of 3.0 or 6.0, with a binder over 6 h. Lanthanum carbonate, calcium acetate/magnesium carbonate, sevelamer carbonate, calcium carbonate and sucroferric oxyhydroxide, 67 mg of each, were used. The experiments were performed in duplicate. The primary outc

SUBMITTER: Schumacher SP 

PROVIDER: S-EPMC6585603 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature