Requirements and Pitfalls of Dialyzer Sieving Coefficients Comparisons.

ABSTRACT: Sieving coefficients reported in dialyzer data sheets and instructions for use (IFUs) indicate the potential of different solutes to pass across a particular membrane. Despite being measured in vitro, sieving coefficient data are often used as a predictor of the clinical performance of dialyzers. Although standards for the measurement of sieving coefficients exist, the stated methodologies do not offer sufficient guidance to ensure comparability of test results between different dialyzers. The aim of this work was to investigate the relationship between sieving coefficients and published clinical performance indicators for two solutes, albumin loss and beta-2 microglobulin (β₂ M) reduction ratio (RR), and to assess the impact of different in vitro test parameters on sieving coef

SUBMITTER: Hulko M 

PROVIDER: S-EPMC6585607 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature