Evaluation of Effects of TGF-β1 Inhibition on Gastric Cancer in Nude Mice by Diffusion Kurtosis Imaging and In-Line X-ray Phase Contrast Imaging With Sequential Histology.

ABSTRACT:

Background

Accurate and complete response evaluation after treatment is important to implement individualized therapy for gastric cancer.

Purpose

To investigate the effectiveness of diffusion kurtosis imaging (DKI) and in-line X-ray phase contrast imaging (ILXPCI) in the assessment of the therapeutic efficacy by transforming growth factor beta 1 (TGF-β1) inhibition.

Study type

Prospective animal study.

Animal model

Thirty nude mice subcutaneous xenotransplantation tumor model of gastric cancer for DKI and 10 peritoneal metastasis nude mice model for ILXPCI.

Field strength/sequence

Examinations before and serially at 7, 14, 21, and 28 days after TGF-β1 inhibition treatment were performed at 3T MRI including T₂ -weighted imaging (T₂ W

SUBMITTER: Shi B 

PROVIDER: S-EPMC6585615 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature