The miRNA biogenesis pathway prevents inappropriate expression of injury response genes in developing and adult Schwann cells.

ABSTRACT: Proper function of the nervous system depends on myelination. In peripheral nerves, Schwann cells (SCs) myelinate axons and the miRNA biogenesis pathway is required for developmental myelination and myelin maintenance. However, regulatory roles of this pathway at different stages of myelination are only partially understood. We addressed the requirement of the core miRNA biogenesis pathway components Dgcr8, Drosha, and Dicer in developing and adult SCs using mouse mutants with a comparative genetics and transcriptomics approach. We found that the microprocessor components Dgcr8 and Drosha are crucial for axonal radial sorting and to establish correct SC numbers upon myelination. Transcriptome analyses revealed a requirement of the microprocessor to prevent aberrantly increased expression o

SUBMITTER: Gokbuget D 

PROVIDER: S-EPMC6585637 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature