Gradient-echo and spin-echo blood oxygenation level-dependent functional MRI at ultrahigh fields of 9.4 and 15.2 Tesla.

ABSTRACT:

Purpose

Sensitivity and specificity of blood oxygenation level-dependent (BOLD) functional MRI (fMRI) is sensitive to magnetic field strength and acquisition methods. We have investigated gradient-echo (GE)- and spin-echo (SE)-BOLD fMRI at ultrahigh fields of 9.4 and 15.2  Tesla.

Methods

BOLD fMRI experiments responding to forepaw stimulation were performed with 3 echo times (TE) at each echo type and B₀ in α-chloralose-anesthetized rats. The contralateral forelimb somatosensory region was selected for quantitative analyses.

Results

At 9.4 T and 15.2 T, average baseline T₂ ^* (n = 9) was 26.6 and 17.1 msec, whereas baseline T₂ value (n = 9) was 35.7 and 24.5 msec, respectively. Averaged stimulation-induced ΔR₂

SUBMITTER: Han S 

PROVIDER: S-EPMC6585650 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature