The effect of realistic geometries on the susceptibility-weighted MR signal in white matter.

ABSTRACT:

Purpose

To investigate the effect of realistic microstructural geometry on the susceptibility-weighted MR signal in white matter (WM), with application to demyelination.

Methods

Previous work has modeled susceptibility-weighted signals under the assumption that axons are cylindrical. In this study, we explored the implications of this assumption by considering the effect of more realistic geometries. A three-compartment WM model incorporating relevant properties based on the literature was used to predict the MR signal. Myelinated axons were modeled with several cross-sectional geometries of increasing realism: nested circles, warped/elliptical circles, and measured axonal geometries from electron micrographs. Signal simulations from the different microstructural geometries

SUBMITTER: Xu T 

PROVIDER: S-EPMC6585669 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature