Acute changes in histopathology and intravascular imaging after catheter-based renal denervation in a porcine model.

ABSTRACT:

Objectives

We first aimed to identify the histopathological changes occurring immediately after renal denervation (RDN) with radiofrequency energy, and then to assess the feasibility of determining procedural success using currently available clinical intravascular imaging techniques.

Background

Catheter-based RDN has been used as an alternative therapy for hypertension. However, no practical endpoint to determine procedural success during treatment has been established.

Methods

A total of 39 ablation lesions were induced in vivo in eight porcine renal arteries and a total of 15 ablation lesions were induced ex vivo in five excised porcine renal arteries with a radiofrequency delivery device. Acute histological changes and appearance on intravascular imaging of the le

SUBMITTER: Sakaoka A 

PROVIDER: S-EPMC6585757 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature