Allograft and patient survival after sequential HSCT and kidney transplantation from the same donor-A multicenter analysis.

ABSTRACT: Tolerance induction through simultaneous hematopoietic stem cell and renal transplantation has shown promising results, but it is hampered by the toxicity of preconditioning therapies and graft-versus-host disease (GVHD). Moreover, renal function has never been compared to conventionally transplanted patients, thus, whether donor-specific tolerance results in improved outcomes remains unanswered. We collected follow-up data of published cases of renal transplantations after hematopoietic stem cell transplantation from the same donor and compared patient and transplant kidney survival as well as function with caliper-matched living-donor renal transplantations from the Austrian dialysis and transplant registry. Overall, 22 tolerant and 20 control patients were included (median observation p

SUBMITTER: Eder M 

PROVIDER: S-EPMC6585795 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature