Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans.

ABSTRACT:

Objective

Alterations in lipids in muscle and plasma have been documented in insulin-resistant people with obesity. Whether these lipid alterations are a reflection of insulin resistance or obesity remains unclear.

Methods

Nondiabetic sedentary individuals not treated with lipid-lowering medications were studied (n = 51). Subjects with body mass index (BMI) > 25 kg/m(2) (n = 28) were stratified based on median glucose infusion rate during a hyperinsulinemic-euglycemic clamp into insulin-sensitive and insulin-resistant groups (above and below median, obesity/insulin-sensitive and obesity/insulin-resistant, respectively). Lean individuals (n = 23) served as a reference group. Lipidomics was performed in muscle and plasma by liquid chromatography electrospray ionization-tandem

SUBMITTER: Tonks KT 

PROVIDER: S-EPMC6585800 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature