Aberrant cell signalling in PBMCs upon IFN-α stimulation in primary Sjogren's syndrome patients associates with type I interferon signature.

ABSTRACT: Primary Sjögren's syndrome (pSS) is a complex systemic autoimmune disease with heterogeneous disease manifestations. Genetic predisposition, hormonal and environmental factors are all thought to contribute to disease etiology and pathogenesis. A better understanding of the disease pathogenesis is required in order to establish new targeted therapies. We analysed MAPK/ERK and JAK/STAT signalling networks in peripheral blood mononuclear cells (PBMCs) upon stimulation with interferon alpha 2b (IFN-α2b) by flow cytometry to define potentially dysfunctional intracellular signalling pathways involved in disease pathogenesis. Cells derived from pSS patients displayed small but significant increases in basal phosphorylation levels of numerous signalling proteins compared to cells from healthy dono

SUBMITTER: Davies R 

PROVIDER: S-EPMC6585835 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature