Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study.

ABSTRACT:

Objectives

Bipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accumulation of early age at onset (AAO) in BD families and have therefore hypothesized that there is a larger genetic contribution to the early-onset cases than to late onset BD. To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients.

Methods

A total of 1995 BD type 1 patients from the Consortium of Lithium Genetics (ConLiGen), PsyCourse and Bonn-Mannheim samples were genotype

SUBMITTER: Kalman JL 

PROVIDER: S-EPMC6585855 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature