Ontology highlight
ABSTRACT:
SUBMITTER: Clausen F
PROVIDER: S-EPMC6585874 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Chemical science 20190522 24
Pinacol boronic esters are highly valuable building blocks in organic synthesis. In contrast to the many protocols available on the functionalizing deboronation of alkyl boronic esters, protodeboronation is not well developed. Herein we report catalytic protodeboronation of 1°, 2° and 3° alkyl boronic esters utilizing a radical approach. Paired with a Matteson-CH<sub>2</sub>-homologation, our protocol allows for formal anti-Markovnikov alkene hydromethylation, a valuable but unknown transformati ...[more]