Mir-421 in plasma as a potential diagnostic biomarker for precancerous gastric lesions and early gastric cancer.

ABSTRACT:

Objective

MicroRNA (miR)-421 plays a key role in cancer progression. It has been reported that circulating miR-421may be a potential tumor marker for the diagnosis of several cancers. However, the role of miR-421 in plasma as a potential biomarker in the diagnosis of precancerous gastric lesions (Pre) and early-stage gastric cancer (GC) remains poorly understood. In this study, we investigated miR-421 in plasma as a novel potential biomarker for the detection of precancerous gastric lesions and early-stage (GC).

Materials & methods

The miRNA content was determined by quantitative real-time polymerase chain reaction (qRT-PCR). MiR-421 content in all subjects was normalized by endogenous miRNA (miR-16). The diagnostic value of miR-421 for Pre and GC was assessed by comparing r

SUBMITTER: Chen J 

PROVIDER: S-EPMC6585904 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature