Targeted metabolomics study of serum bile acid profile in patients with end-stage renal disease undergoing hemodialysis.

ABSTRACT:

Background

Bile acids are important metabolites of intestinal microbiota, which have profound effects on host health. However, whether metabolism of bile acids is involved in the metabolic complications of end-stage renal disease (ESRD), and the effects of bile acids on the prognosis of ESRD remain obscure. Therefore, this study investigated the relationship between altered bile acid profile and the prognosis of ESRD patients.

Methods

A targeted metabolomics approach based on ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to determine the changes in serum bile acids between ESRD patients (n = 77) and healthy controls (n = 30). Univariate and multivariate statistical analyses were performed to screen the differential propo

SUBMITTER: Li R 

PROVIDER: S-EPMC6585905 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature