Evaluation of resorbable polydioxanone and polyglycolic acid meshes in a rat model of ventral hernia repair.

ABSTRACT: The objective of this study was to evaluate physical, mechanical, and biological properties of the polydioxanone (PDO) monofilament meshes and polyglycolide (PGA) polyfilament meshes in comparison with Permacol^® implants. In rat experimental model, a 1.5 × 2.0 cm defect in abdominal wall was reconstructed by using the Permacol surgical implant or knitted meshes produced from either PDO monofilament, or PGA multifilament. The implant sites were assessed for the tensile strength and the extents of material resorption, host inflammatory response and host tissue replacement on days 3, 10, 30, or 60 after the surgery. The PDO and PGA meshes were rapidly pervaded by the host connective tissue with elements of skeletal muscle histogenesis. The degree of adhesions was significantly high

SUBMITTER: Fatkhudinov T 

PROVIDER: S-EPMC6585936 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature