On the sensitivity of quantitative susceptibility mapping for measuring trabecular bone density.

ABSTRACT:

Purpose

To develop a methodological framework to simultaneously measure R2* and magnetic susceptibility in trabecularized yellow bone marrow and to investigate the sensitivity of Quantitative Susceptibility Mapping (QSM) for measuring trabecular bone density using a non-UTE multi-gradient echo sequence.

Methods

The ankle of 16 healthy volunteers and two patients was scanned using a time-interleaved multi-gradient-echo (TIMGRE) sequence. After field mapping based on water-fat separation methods and background field removal based on the Laplacian boundary value method, three different QSM dipole inversion schemes were implemented. Mean susceptibility values in regions of different trabecular bone density in the calcaneus were compared to the corresponding values in the R2* map

SUBMITTER: Diefenbach MN 

PROVIDER: S-EPMC6585956 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature