Clinical factors predicting treatment resistant depression: affirmative results from the European multicenter study.

ABSTRACT:

Objectives

Clinical variables were investigated in the 'treatment resistant depression (TRD)- III' sample to replicate earlier findings by the European research consortium 'Group for the Study of Resistant Depression' (GSRD) and enable cross-sample prediction of treatment outcome in TRD.

Experimental procedures

TRD was defined by a Montgomery and Åsberg Depression Rating Scale (MADRS) score ≥22 after at least two antidepressive trials. Response was defined by a decline in MADRS score by ≥50% and below a threshold of 22. Logistic regression was applied to replicate predictors for TRD among 16 clinical variables in 916 patients. Elastic net regression was applied for prediction of treatment outcome.

Results

Symptom severity (odds ratio (OR) = 3.31), psychotic symptoms (

SUBMITTER: Kautzky A 

PROVIDER: S-EPMC6586002 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature