Comprehensive comparison of monotherapies for psychiatric hospitalization risk in bipolar disorders.

ABSTRACT:

Objectives

This study compared 29 drugs for risk of psychiatric hospitalization in bipolar disorders, addressing the evidence gap on the >50 drugs used by US patients for treatment.

Methods

The Truven Health Analytics MarketScan^® database was used to identify 190 894 individuals with bipolar or schizoaffective disorder who filled a prescription for one of 29 drugs of interest: lithium, first- or second-generation antipsychotics, mood-stabilizing anticonvulsants, and antidepressants. Competing risks regression survival analysis was used to compare drugs for risk of psychiatric hospitalization, adjusting for patient age, sex, comorbidities, and pretreatment medications. Other competing risks were ending monotherapy and non-psychiatric hospitalization.

Results

SUBMITTER: Nestsiarovich A 

PROVIDER: S-EPMC6586061 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature