Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.

ABSTRACT: Aberrant translational repression is a feature of multiple neurodegenerative diseases. The association between disease-linked proteins and stress granules further implicates impaired stress responses in neurodegeneration. However, our knowledge of the proteins that evade translational repression is incomplete. It is also unclear whether disease-linked proteins influence the proteome under conditions of translational repression. To address these questions, a quantitative proteomics approach was used to identify proteins that evade stress-induced translational repression in arsenite-treated cells expressing either wild-type or amyotrophic lateral sclerosis (ALS)-linked mutant FUS. This study revealed hundreds of proteins that are actively synthesized during stress-induced translational repre

SUBMITTER: Baron DM 

PROVIDER: S-EPMC6586143 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature