Refractory juvenile myoclonic epilepsy: a meta-analysis of prevalence and risk factors.

ABSTRACT:

Background and purpose

Juvenile myoclonic epilepsy (JME) is a common epilepsy syndrome for which treatment response is generally assumed to be good. We aimed to determine the prevalence and prognostic risk factors for refractoriness of JME.

Methods

We systematically searched PubMed and EMBASE and included 43 eligible studies, reporting seizure outcome after antiepileptic drug (AED) treatment in JME cohorts. We defined refractory JME as persistence of any seizure despite AED treatment and performed a random-effects meta-analysis to assess the prevalence of refractory JME and of seizure recurrence after AED withdrawal in individuals with well-controlled seizures. Studies reporting potential prognostic risk factors in relation to seizure outcome were included for subsequent met

SUBMITTER: Stevelink R 

PROVIDER: S-EPMC6586162 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature