Community spread and late season increased incidence of oseltamivir-resistant influenza A(H1N1) viruses in Norway 2016.

ABSTRACT:

Background

Antiviral resistance in Norwegian influenza viruses is rare. Only one A(H1N1)pdm09 virus from May 2015 had been found resistant to oseltamivir since the introduction of these viruses in 2009.

Objectives

Surveillance of antiviral resistance is part of the Norwegian surveillance system, to rapidly detect the development of antiviral-resistant viruses and spread in the community. We describe the spread of oseltamivir-resistant A(H1N1)pdm09 viruses in Norway in the 2016-17 season, found as part of the routine surveillance.

Methods

Influenza H1N1 viruses were analysed for antiviral resistance by pyrosequencing, neuraminidase susceptibility assay and by Sanger sequencing of the HA and NA genes.

Results

During the 2015-16 influenza season, 3% of all A(H1N1)

SUBMITTER: Bragstad K 

PROVIDER: S-EPMC6586177 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature