Sequential Functionalization of meta-C-H and ipso-C-O Bonds of Phenols.

ABSTRACT: The use of a template as a linchpin motif in directed remote C-H functionalization is a versatile yet relatively underexplored strategy. We have developed a template-directed approach to realizing one-pot sequential palladium-catalyzed meta-selective C-H olefination of phenols, and nickel-catalyzed ipso-C-O activation and arylation. Thus, this bifunctional template converts phenols to synthetically useful 1,3-disubstituted arenes.

SUBMITTER: Xu J 

PROVIDER: S-EPMC6586216 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature