The Diverse Genomic Landscape of Clinically Low-risk Prostate Cancer.

ABSTRACT:

Background

Among men with clinically low-risk prostate cancer, we have previously documented heterogeneity in terms of clinical characteristics and genomic risk scores.

Objective

To further study the underlying tumor biology of this patient population, by interrogating broader patterns of gene expression among men with clinically low-risk tumors.

Design, setting, and participants

Prostate biopsies from 427 patients considered potentially suitable for active surveillance underwent central pathology review and genome-wide expression profiling. These cases were compared with 1290 higher-risk biopsy cases with diverse clinical features from a prospective genomic registry.

Outcome measurements and statistical analysis

Average genomic risk (AGR) was determined from 1

SUBMITTER: Cooperberg MR 

PROVIDER: S-EPMC6586429 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature