Physiologically Based Pharmacokinetic Modeling for Trimethoprim and Sulfamethoxazole in Children.

ABSTRACT:

Objective

The aims of this study were to (1) determine whether opportunistically collected data can be used to develop physiologically based pharmacokinetic (PBPK) models in pediatric patients; and (2) characterize age-related maturational changes in drug disposition for the renally eliminated and hepatically metabolized antibiotic trimethoprim (TMP)-sulfamethoxazole (SMX).

Methods

We developed separate population PBPK models for TMP and SMX in children after oral administration of the combined TMP-SMX product and used sparse and opportunistically collected plasma concentration samples to validate our pediatric model. We evaluated predictability of the pediatric PBPK model based on the number of observed pediatric data out of the 90% prediction interval. We performed dosing

SUBMITTER: Thompson EJ 

PROVIDER: S-EPMC6586496 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature