Somatotopically specific primary somatosensory connectivity to salience and default mode networks encodes clinical pain.

ABSTRACT: Although several studies have found that chronic pain is characterized by increased cross-network connectivity between salience network, sensorimotor network, and default mode network (DMN), a large sample-size investigation allowing for a more reliable evaluation of somatotopic specificity and subgroup analyses with linkage to clinical pain intensity has been lacking. We enrolled healthy adults and a large cohort of patients (N = 181) suffering from chronic low back pain (cLBP). To specifically link brain connectivity with clinical pain intensity, patients were scanned at baseline and after performing physical maneuvers that exacerbated pain. Compared with healthy adults, patients with cLBP demonstrated increased connectivity between the functionally localized back representation in the p

SUBMITTER: Kim J 

PROVIDER: S-EPMC6586503 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature