Methylation and transcription patterns are distinct in IDH mutant gliomas compared to other IDH mutant cancers.

ABSTRACT: Mutations in isocitrate dehydrogenases 1 and 2 (IDH^mut) are present in a variety of cancers, including glioma, acute myeloid leukemia (AML), melanoma, and cholangiocarcinoma. These mutations promote hypermethylation, yet it is only a favorable prognostic marker in glioma, for reasons that are unclear. We hypothesized that the patterns of DNA methylation, and transcriptome profiles, would vary among IDH^mut cancers, especially gliomas. Using Illumina 450K and RNA-Seq data from The Cancer Genome Atlas, we show that of 365,092 analyzed CpG sites, 70,591 (19%) were hypermethylated in IDH^mut gliomas compared to wild-type (IDH^wt) gliomas, and only 3%, 2%, and 4% of CpG sites were hypermethylated in IDH^mut AML, melanoma, and cholangiocarcinoma

SUBMITTER: Unruh D 

PROVIDER: S-EPMC6586617 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature