T-bet⁺ lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer.

ABSTRACT:

Purpose

T-box transcription factor 21 (T-bet), which is the master regulator of effector T-cell activation, is derived by stimulation of T-cell receptors. In this study, we focused on T-bet and examined the function of activated T cells.

Methods

This study included 242 patients with primary triple-negative breast cancer (TNBC) who underwent resection without neoadjuvant chemotherapy between January 2004 and December 2014. The immunohistochemistry scoring for CD8 and T-bet expression on tumor-infiltrating lymphocytes (TILs) was defined as ≥ 30 per 6.25 × 10^-3 mm².

Results

Of the 242 TNBC cases, CD8 was positively expressed in 127 (52.5%) tumors, and T-bet was positively expressed in 67 (27.7%) tumors. T-bet expression was significantly correlated

SUBMITTER: Mori H 

PROVIDER: S-EPMC6586701 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature