PolyBall: A new adsorbent for the efficient removal of endotoxin from biopharmaceuticals.

ABSTRACT: The presence of endotoxin, also known as lipopolysaccharides (LPS), as a side product appears to be a major drawback for the production of certain biomolecules that are essential for research, pharmaceutical, and industrial applications. In the biotechnology industry, gram-negative bacteria (e.g., Escherichia coli) are widely used to produce recombinant products such as proteins, plasmid DNAs and vaccines. These products are contaminated with LPS, which may cause side effects when administered to animals or humans. Purification of LPS often suffers from product loss. For this reason, special attention must be paid when purifying proteins aiming a product as free as possible of LPS with high product recovery. Although there are a number of methods for removing LPS, the question about how LP

SUBMITTER: Razdan S 

PROVIDER: S-EPMC6586805 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature