Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma.

ABSTRACT: Asthma is a chronic inflammatory disorder of the airways. Disease presentation varies greatly in terms of cause, development, severity, and response to medication, and thus the condition has been subdivided into a number of asthma phenotypes. There is still an unmet need for the identification of phenotype-specific markers and accompanying molecular tools that facilitate the classification of asthma phenotype. To this end, we utilised a range of molecular tools to characterise a well-defined group of female adults with poorly controlled atopic asthma associated with house dust mite (HDM) allergy, relative to non-asthmatic control subjects. Circulating messenger RNA (mRNA) and microRNA (miRNA) were sequenced and quantified, and a differential expression analysis of the two RNA populations p

SUBMITTER: Whittle E 

PROVIDER: S-EPMC6586825 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature