Ontology highlight
ABSTRACT:
SUBMITTER: Banhos Danneskiold-Samsoe N
PROVIDER: S-EPMC6586826 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Banhos Danneskiold-Samsøe Niels N Sonne Si Brask SB Larsen Jeppe Madura JM Hansen Ann Normann AN Fjære Even E Isidor Marie Sophie MS Petersen Sidsel S Henningsen Jeanette J Severi Ilenia I Sartini Loris L Schober Yvonne Y Wolf Jacqueline J Nockher W Andreas WA Wolfrum Christian C Cinti Saverio S Sina Christian C Hansen Jacob B JB Madsen Lise L Brix Susanne S Kristiansen Karsten K
Scientific reports 20190620 1
Cyclooxygenases are known as important regulators of metabolism and immune processes via conversion of C20 fatty acids into various regulatory lipid mediators, and cyclooxygenase activity has been implicated in browning of white adipose tissues. We generated transgenic (TG) C57BL/6 mice expressing the Ptgs2 gene encoding cyclooxygenase-2 (COX-2) in mature adipocytes. TG mice fed a high-fat diet displayed marginally lower weight gain with less hepatic steatosis and a slight improvement in insulin ...[more]