Ontology highlight
ABSTRACT:
SUBMITTER: Sharma AD
PROVIDER: S-EPMC6586937 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Sharma Anup D AD McCoy Laurie L Jacobs Elizabeth E Willey Hannah H Behn Jordan Q JQ Nguyen Hieu H Bolon Brad B Curley J Lowry JL Moore Michael J MJ
Scientific reports 20190620 1
Development of "organ-on-a-chip" systems for neuroscience applications are lagging due in part to the structural complexity of the nervous system and limited access of human neuronal & glial cells. In addition, rates for animal models in translating to human success are significantly lower for neurodegenerative diseases. Thus, a preclinical in vitro human cell-based model capable of providing critical clinical metrics such as nerve conduction velocity and histomorphometry are necessary to improv ...[more]