Evaluation of six blood-based age prediction models using DNA methylation analysis by pyrosequencing.

ABSTRACT: DNA methylation has been identified as the most promising molecular biomarker for the prediction of age. Several DNA methylation-based models have been proposed for age prediction based on blood samples, using mainly pyrosequencing. These methods present different performances for age prediction and have rarely, if ever, been evaluated and intercompared in an independent validation study. Here, for the first time, we evaluate and compare six blood-based age prediction models (Bekaert¹, Park², Thong³, Weidner⁴, and the Zbiec-Piekarska 1⁵ and Zbiec-Piekarska 2⁶), using DNA methylation analysis by pyrosequencing on 100 blood samples from French individuals aged between 19-65 years. For each model, we perform correlation analysi

SUBMITTER: Daunay A 

PROVIDER: S-EPMC6586942 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature