Relationship between genetic variation in the α_2A-adrenergic receptor and the cardiovascular effects of dexmedetomidine in the Chinese Han population.

ABSTRACT: There are differences in individual cardiovascular responses to the administration of dexmedetomidine, a highly selective α_2A-adrenergic receptor (ADRA2A) agonist. The aim of this study was to investigate ADRA2A gene polymorphisms in the Chinese Han population and their association with the cardiovascular response to intravenous dexmedetomidine infusion. Sixty elective surgery patients of Chinese Han nationality were administered 1 µg/kg dexmedetomidine intravenously over 10 min as a premedication. ADRA2A C-1291G and A1780G polymorphism status was determined in these patients, and their relationships to changes in blood pressure and heart rate after dexmedetomidine administration were analyzed. There were neither significant differences in systolic or diastolic blood pressure ch

SUBMITTER: Zhu SJ 

PROVIDER: S-EPMC6586997 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature