Cerebellar atrophy and its contribution to motor and cognitive performance in multiple system atrophy.

ABSTRACT:

Objective

Neuroanatomical differences in the cerebellum are among the most consistent findings in multiple system atrophy (MSA) patients. This study performed a detailed cerebellar morphology in MSA patients and its two subtypes: MSA-P (parkinson's symptoms predominate) and MSA-C (cerebellar symptoms predominant), and their relations to profiles of motor and cognitive deficits.

Materials and methods

Structure MRI data were acquired from 63 healthy controls and 61 MSA patients; voxel-based morphometry and the Spatially Unbiased Infratentorial Toolbox cerebellar atlas were performed to identify the cerebellar gray volume changes in MSA and its subtypes. Further, the gray matter changes were correlated with the clinical motor/cognitive scores.

Results

Patients with MSA e

SUBMITTER: Yang H 

PROVIDER: S-EPMC6587071 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature