RUNX2 overexpression and PTEN haploinsufficiency cooperate to promote CXCR7 expression and cellular trafficking, AKT hyperactivation and prostate tumorigenesis.

ABSTRACT: Rationale: The overall success rate of prostate cancer (PCa) diagnosis and therapy has been improved over the years. However, genomic and phenotypic heterogeneity remains a major challenge for effective detection and treatment of PCa. Efforts to better classify PCa into functional subtypes and elucidate the molecular mechanisms underlying prostate tumorigenesis and therapy resistance are warranted for further improvement of PCa outcomes. Methods: We generated Cre⁺;Runx2-cTg;Pten^p/+ (Runx2-Pten double mutant) mice by crossbreeding Cre⁺;Runx2-cTg males with Pten conditional (Pten^p/p) females. By using Hematoxylin and Eosin (H&E) staining, SMA and Masson's Trichrome staining, we i

SUBMITTER: Bai Y 

PROVIDER: S-EPMC6587168 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature