Frailty effects on non-demented cognitive trajectories are moderated by sex and Alzheimer's genetic risk.

ABSTRACT:

Background

Age-related frailty reflects cumulative multisystem physiological and health decline. Frailty increases the risk of adverse brain and cognitive outcomes, including differential decline and dementia. In a longitudinal sample of non-demented older adults, we examine whether (a) the level and/or change in frailty predicts trajectories across three cognitive domains (memory, speed, and executive function (EF)) and (b) prediction patterns are modified by sex or Alzheimer's genetic risk (Apolipoprotein E (APOE)).

Methods

Participants (n = 632; M age = 70.7, range 53-95; 3 waves) were from the Victoria Longitudinal Study. After computing a frailty index, we used latent growth modeling and path analysis to test the frailty effects on level and change in three latent varia

SUBMITTER: Thibeau S 

PROVIDER: S-EPMC6587247 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature